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Transcranial Ultrasound Stimulation as a Novel Non-invasive Neuromodulation for Movement Disorders

  • Toronto Western Hospital 399 Bathurst Street Toronto, ON, M5T 2S6 Canada (map)

Dr. Robert Chen is a Senior Scientist at Krembil Brain Institute. Dr. Chen’s lab is currently investigating the organization of cortical inhibitory and excitatory pathways in the human motor cortex, cortical plasticity, pathophysiology of movement disorders such as Parkinson disease and dystonia, the mechanisms of action of deep brain stimulation inhibitory functions of the basal ganglia and development of novel neuromodulation methods.

The techniques used include single pulse, paired pulse and repetitive transcranial magnetic stimulation, transcranial focused ultrasound (FUS), functional magnetic resonance imaging (MRI), electroencephalographic (EEG) recordings of cortical rhythms and movement-related cortical potentials, magnetoencephalography (MEG) and recordings of local field potentials from deep brain stimulation electrodes in the basal ganglia.